| Identification | Back Directory | [Name]
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)- | [CAS]
102271-49-8 | [Synonyms]
PGS-IN-1
α-(3,5-di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)-
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)- (9CI) | [Molecular Formula]
C19H26O3 | [MOL File]
102271-49-8.mol | [Molecular Weight]
302.41 |
| Chemical Properties | Back Directory | [Boiling point ]
429.1±45.0 °C(Predicted) | [density ]
1.096±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
11.51±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(E)-KME-4 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM. | [IC 50]
5-Lipoxygenase: 1.05 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Katsumi I, et al. Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):121-9. DOI:10.1248/cpb.34.121 |
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