| Identification | Back Directory | [Name]
[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol | [CAS]
1023814-45-0 | [Synonyms]
OUL245
1,2,4-Triazolo[3,4-b]benzothiazol-7-ol
[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol | [Molecular Formula]
C8H5N3OS | [MDL Number]
MFCD09880852 | [MOL File]
1023814-45-0.mol | [Molecular Weight]
191.21 |
| Hazard Information | Back Directory | [Uses]
OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM[1]. | [IC 50]
PARP2: 44 nM (IC50); PARP-1: 570 nM (IC50); PARP3: 8.8 μM (IC50); PARP4: 6.0 μM (IC50); TNKS1: 1.6 μM (IC50); TNKS2: 370 μM (IC50); PARP10: 2.9 μM (IC50); PARP14: 6.7 μM (IC50); PARP15: 2.0 μM (IC50) | [References]
[1] Murthy S, et al. [1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J Med Chem. 2023 Jan 4. DOI:10.1021/acs.jmedchem.2c01460 |
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