| Identification | Back Directory | [Name]
(S,S)-2-[3-(5-amino-1-carboxy-pentyl)-ureido]-pentanedioic acid | [CAS]
1025796-32-0 | [Synonyms]
GCPII-IN-1
(S,S)-2-[3-(5-amino-1-carboxy-pentyl)-ureido]-pentanedioic acid
L-Glutamic acid, N-[[[(1S)-5-amino-1-carboxypentyl]amino]carbonyl]-
(S)?-?2-?(3-?((S)?-?5-?amino-?1-?carboxypentyl)?ureido)?pentanedioic acid | [Molecular Formula]
C12H21N3O7 | [MDL Number]
MFCD32901292 | [MOL File]
1025796-32-0.mol | [Molecular Weight]
319.31 |
| Chemical Properties | Back Directory | [Boiling point ]
682.1±55.0 °C(Predicted) | [density ]
1.390±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.76±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
GCPII-IN-1 is a glutamate carboxypeptidase II (GCPII, or PSMA) inhibitor. | [Uses]
GCPII-IN-1 is a glutamate carboxypeptidase II (GCPII, or PSMA) inhibitor scaffold with a Ki of 44.3 nM[1]. | [References]
[1] Jan Tykvart, et al. Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg Med Chem. 2014 Aug 1;22(15):4099-108. DOI:10.1016/j.bmc.2014.05.061 |
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