| Identification | Back Directory | [Name]
2-Hydroxy-1,5-naphthyridine | [CAS]
10261-82-2 | [Synonyms]
1,5-naphthyridin-2-ol
1,5-Naphthyridin-2(1H)
1H-1,5-naphthyridin-2-one
1,5-Naphthyridin-2(1H)-one
2-Hydroxy-1,5-naphthyridine
2- hydroxy-1, 5-naphthidine
1,5-Naphthyridine-2(1H)-one | [Molecular Formula]
C8H6N2O | [MDL Number]
MFCD11877925 | [MOL File]
10261-82-2.mol | [Molecular Weight]
146.15 |
| Chemical Properties | Back Directory | [Melting point ]
258 °C | [Boiling point ]
391.8±42.0 °C(Predicted) | [density ]
1.267±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
11.29±0.20(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Uses]
1,5-Naphthyridin-2(1H)-one is used as a reactant in the design of brain penetrant JNK inhibitors for prevention of neurodegeneration. | [Synthesis]
The general procedure for the synthesis of 1,5-naphthyridin-2(1H)-one from the compound (CAS: 27017-69-2) was as follows: intermediate 2 (15.8 g) was dissolved in 6N hydrochloric acid solution (100 mL) and the reaction was stirred at 110 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The solid was dried by suction filtration. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and the pH was adjusted to 6-7 with solid sodium hydroxide. the precipitated solid was separated by filtration and dried by suction with a sintered funnel for 2 h, followed by vacuum drying at 45 °C to afford the target product 1,5-naphthyridin-2(1H)-one (14.4 g, 98% yield). [ES MS] m/z 147 (MH+). | [References]
[1] Patent: EP2080761, 2009, A1. Location in patent: Page/Page column 16
[2] Patent: WO2010/81874, 2010, A1. Location in patent: Page/Page column 18 |
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