| Identification | Back Directory | [Name]
Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tyrosyl-L-seryl-L-leucyl-L-α-glutamyl-L-tryptophyl-L-lysyl-L-prolyl- | [CAS]
102634-23-1 | [Synonyms]
Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tyrosyl-L-seryl-L-leucyl-L-α-glutamyl-L-tryptophyl-L-lysyl-L-prolyl- | [Molecular Formula]
C58H79N15O15 | [MOL File]
102634-23-1.mol | [Molecular Weight]
1226.34 |
| Hazard Information | Back Directory | [Uses]
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models[1]. | [in vivo]
Lamprey LH-RH I (5-200 μg/kg; i.p.; single dose or twice) elevates plasma steroid levels and stimulates lamprey ovulation[1].
| Animal Model: | Female sea-run sea lampreys[1] | | Dosage: | 5 μg/kg, 50 μg/kg, 100 μg/kg, 200 μg/kg; dissolved in 0.6% NaCl in distilled water | | Administration: | Intraperitoneal injection; single dose or twice; observed for 30 days | | Result: | Significantly increased estradiol in a dose-related manner.
Resulted 80% of the lampreys ovulation at 200 or 100 μg/kg compared in a doserelated manner. |
| [References]
[1] Sower SA, et al. Comparative biological properties of lamprey gonadotropin-releasing hormone in vertebrates. Endocrinology. 1987 Feb;120(2):773-9. DOI:10.1210/endo-120-2-773
[2] King JC, et al. Neuronal systems immunoreactive with antiserum to lamprey gonadotropin-releasing hormone in the brain of Petromyzon marinus. Cell Tissue Res. 1988 Jul;253(1):1-8. DOI:10.1007/BF00221732 |
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