| Identification | Back Directory | [Name]
AMG-009 | [CAS]
1027847-67-1 | [Synonyms]
AMG-009
AMG009,AMG 009
Benzeneacetic acid, 4-[4-[(butylamino)carbonyl]-2-[[(2,4-dichlorophenyl)sulfonyl]amino]phenoxy]-3-methoxy- | [Molecular Formula]
C26H26Cl2N2O7S | [MDL Number]
MFCD30532598 | [MOL File]
1027847-67-1.mol | [Molecular Weight]
581.46 |
| Chemical Properties | Back Directory | [Melting point ]
148.6 °C | [density ]
1.403±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.20±0.10(Predicted) | [color ]
Pale Brown |
| Hazard Information | Back Directory | [Uses]
4-[4-[(Butylamino)carbonyl]-2-[[(2,4-dichlorophenyl)sulfonyl]amino]phenoxy]-3-methoxy-benzeneacetic Acid is a dual??prostanoid D receptor??(DP) and??chemoattractant receptor-homologous molecule expressed on Th2 cells??(CRTH2) antagonist. DP and CRTH2 are involved in mediating allergic reactions (asthma, allergic rhinitis, and atopic dermatitis). Compounds that inhibit these receptors may hold potential for treating allergic diseases. | [in vivo]
AMG 009 (3, 10 or 30 mg/kg, s.c.) results in a dose dependent decrease in airway resistance provoked by PGD2 aerosol in an acute guinea pig model[1]. In a guinea pig model of PGD2-induced airway constriction, AMG 009 significantly improves DP potency, with Kb of 82 nM[2]. | [IC 50]
DP: 12 nM (IC50); CRTH2: 3 nM (IC50) |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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