ChemicalBook--->CAS DataBase List--->1029939-86-3

1029939-86-3

1029939-86-3 Structure

1029939-86-3 Structure
IdentificationBack Directory
[Name]

Ralimetinib
[CAS]

1029939-86-3
[Synonyms]

OZ439
Ralimetinib
Artefenomel (OZ439)
XLCNVWUKICLURR-UHFFFAOYSA-N
Morpholine, 4-[2-(4-cis-dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decan]-4-ylphenoxy)ethyl]-
[Molecular Formula]

C28H39NO5
[MDL Number]

MFCD28902251
[MOL File]

1029939-86-3.mol
[Molecular Weight]

469.61
Chemical PropertiesBack Directory
[Melting point ]

152-154 °C
[Boiling point ]

608.7±55.0 °C(Predicted)
[density ]

1.24±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C, protect from light, stored under nitrogen
[solubility ]

DMSO: 10 mM
[form ]

A solid
[pka]

6.46±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2[1][2].
[IC 50]

Plasmodium
[References]

[1] Jo?lle Jourdan, et al. Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel). ACS Infect Dis. 2016 Jan 8;2(1):54-61. DOI:10.1021/acsinfecdis.5b00090
[2] Tania Massignan, et al. Antimalarial Artefenomel Inhibits Human SARS-CoV-2 Replication in Cells while Suppressing the Receptor ACE2.
[3] Robert L Clark, et al. Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate. Birth Defects Res. 2018 Apr 17;110(7):553-578. DOI:10.1002/bdr2.1170
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