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1030133-34-6

1030133-34-6 Structure

1030133-34-6 Structure
IdentificationBack Directory
[Name]

1H-Pyrrole-3-sulfonamide, 1,2-dimethyl-N-(5-methyl-3-isoxazolyl)-5-[4-methyl-5-[(4-methyl-1-piperidinyl)carbonyl]-2-thiazolyl]-
[CAS]

1030133-34-6
[Synonyms]

Cas9-IN-2
1H-Pyrrole-3-sulfonamide, 1,2-dimethyl-N-(5-methyl-3-isoxazolyl)-5-[4-methyl-5-[(4-methyl-1-piperidinyl)carbonyl]-2-thiazolyl]-
[Molecular Formula]

C21H27N5O4S2
[MOL File]

1030133-34-6.mol
[Molecular Weight]

477.6
Chemical PropertiesBack Directory
[Boiling point ]

725.0±70.0 °C(Predicted)
[density ]

1.46±0.1 g/cm3(Predicted)
[pka]

7.04±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].
[References]

[1] Lee SW, et al. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening. J Med Chem. 2022;65(4):3266-3305. DOI:10.1021/acs.jmedchem.1c01834
1030133-34-6 suppliers list
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Website:
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