Identification | Back Directory | [Name]
Methanone, [(7R)-4-(4-amino-5-methylthieno[2,3-d]pyrimidin-2-yl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl][2-(2H-1,2,3-triazol-2-yl)phenyl]- | [CAS]
1030377-48-0 | [Synonyms]
DORA42 DORA-42 DORA 42 Methanone, [(7R)-4-(4-amino-5-methylthieno[2,3-d]pyrimidin-2-yl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl][2-(2H-1,2,3-triazol-2-yl)phenyl]- | [Molecular Formula]
C22H24N8OS | [MOL File]
1030377-48-0.mol | [Molecular Weight]
448.54 |
Hazard Information | Back Directory | [Description]
DORA 42 is a dual orexin receptor antagonist (OX1R and OX2R antagonist or DORA). | [Uses]
DORA 42 is a dual orexin 1 and orexin 2 receptor antagonist with sleep efficacy in rats. DORA 42 is promising for research of insomnia[1]. | [References]
[1] Roecker AJ, et al. Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis. Bioorg Med Chem Lett. 2014 May 1;24(9):2079-85. DOI:10.1016/j.bmcl.2014.03.052 |
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