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1030377-48-0

1030377-48-0 Structure

1030377-48-0 Structure
IdentificationBack Directory
[Name]

Methanone, [(7R)-4-(4-amino-5-methylthieno[2,3-d]pyrimidin-2-yl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl][2-(2H-1,2,3-triazol-2-yl)phenyl]-
[CAS]

1030377-48-0
[Synonyms]

DORA42
DORA-42
DORA 42
Methanone, [(7R)-4-(4-amino-5-methylthieno[2,3-d]pyrimidin-2-yl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl][2-(2H-1,2,3-triazol-2-yl)phenyl]-
[Molecular Formula]

C22H24N8OS
[MOL File]

1030377-48-0.mol
[Molecular Weight]

448.54
Chemical PropertiesBack Directory
[Boiling point ]

750.8±70.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[pka]

7.77±0.40(Predicted)
Hazard InformationBack Directory
[Description]

DORA 42 is a dual orexin receptor antagonist (OX1R and OX2R antagonist or DORA).
[Uses]

DORA 42 is a dual orexin 1 and orexin 2 receptor antagonist with sleep efficacy in rats. DORA 42 is promising for research of insomnia[1].
[References]

[1] Roecker AJ, et al. Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis. Bioorg Med Chem Lett. 2014 May 1;24(9):2079-85. DOI:10.1016/j.bmcl.2014.03.052
1030377-48-0 suppliers list
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