| Identification | Back Directory | [Name]
MK-8245 | [CAS]
1030612-87-3 | [Synonyms]
CS-116
MK-8245
MK8245 analog
MK-8245 analog
MK-8245-analog
MK 8245 analog
2-(5-(5-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-2H-tetrazol-2-yl)ac
2-(5-(5-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-2H-tetrazol-2-yl)aceti
5-[5-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-2H-tetrazole-2-acetic acid
2H-Tetrazole-2-acetic acid, 5-[5-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-
2-(5-(5-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-2H-tetrazol-2-yl)acetic acid
(5-{5-[4-(2-broMo-5-fluorophenoxy)piperidin-1-yl]-[1,3,4]-thiadiazol-2-yl}-2H-tetrazol-2-yl)acetic acid | [Molecular Formula]
C16H15BrFN7O3S | [MDL Number]
MFCD20039621 | [MOL File]
1030612-87-3.mol | [Molecular Weight]
484.3 |
| Hazard Information | Back Directory | [Uses]
MK-8245 analog (compound 6) is a potent stearoyl-CoA desaturase (SCD) inhibitor with an IC50 of 7 nM for rat SCD. MK-8245 analog has antidiabetic and antidyslipidemic effects[1]. | [References]
[1] Renata M Oballa, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96. DOI:10.1021/jm200319u |
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Wuhan Topule
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www.weikeqi-biotech.com/ |
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