| Identification | Back Directory | [Name]
Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one, 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]- | [CAS]
1031411-94-5 | [Synonyms]
ACC1/2-IN-2
6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)spiro[chroman-2,4'-piperidin]-4-one
Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one, 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]- | [Molecular Formula]
C24H25N3O3 | [MOL File]
1031411-94-5.mol | [Molecular Weight]
403.47 |
| Hazard Information | Back Directory | [Uses]
ACC1/2-IN-2 (compound PF-3) is a potent ACC1/2 inhibitor with IC50 values of 22 and 48 nM for ACC1 and ACC2, respectively. ACC1/2-IN-2 has antiproliferation activity and can be used for cancer research[1]. | [References]
[1] Wei Q, et al. Design, synthesis and biological evaluation of novel chroman derivatives as non-selective acetyl-CoA carboxylase inhibitors. Bioorg Chem. 2020 Aug;101:103943. DOI:10.1016/j.bioorg.2020.103943 |
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