| Identification | Back Directory | [Name]
H-Gly-Arg-pNA | [CAS]
103192-40-1 | [Synonyms]
GR-PNA
H-Gly-Arg-pNA
Glycine-L-Argininep-nitroanilide dihydrochloride≥ 98% (HPLC) | [Molecular Formula]
C14H21N7O4 | [MDL Number]
MFCD00083360 | [MOL File]
103192-40-1.mol | [Molecular Weight]
351.36 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Uses]
Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal [1][2]. | [References]
[1] Hutchinson DW, et, al. The preparation and properties of immobilised dipeptidyl-aminopeptidase I (cathepsin C). Biochim Biophys Acta. 1987 Nov 5;916(1):1-4. DOI:10.1016/0167-4838(87)90203-2
[2] Potempa J, et, al. Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis. J Biol Chem. 1998 Aug 21;273(34):21648-57. DOI:10.1074/jbc.273.34.21648 |
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