| Identification | Back Directory | [Name]
3-AMino-azepane-1-carboxylic acid tert-butyl ester | [CAS]
1032684-85-7 | [Synonyms]
3615-A4
EOS-60818
Nazartinib intermediate
(R)-1-Boc-3-aMinoazepane
(R)-3-Amino-1-Boc-azepane
(S)-Methyl 3-(1-aMinoethyl)benzoate
tert-butyl(R)-3-aminoazepane-1-carboxylate
(R)-tert-butyl 3-aMinoazepane-1-carboxylate
tert-Butyl (3R)-3-AMinoazepane-
1-carboxylate
(3R)-Amino-azepane-1-carboxylic acid tert-butyl ester
(R)-3-AMino-azepane-1-carboxylic acid tert-butyl ester
(3R)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester
1,1-Dimethylethyl (3R)-3-aminohexahydro-1H-azepine-1-carboxylate
(3R)-3-AMinohexahydro-1H-azepine-1-carboxylic acid tert-butyl ester
(3R)-3-AMinohexahydro-1H-azepine-1-carboxylic Acid 1,1-DiMethylethyl Ester
1H-Azepine-1-carboxylic acid, 3-aMinohexahydro-, 1,1-diMethylethyl ester, (3R)- | [Molecular Formula]
C11H22N2O2 | [MDL Number]
MFCD11041391 | [MOL File]
1032684-85-7.mol | [Molecular Weight]
214.305 |
| Questions And Answer | Back Directory | [Synthesis]
In a three-necked flask equipped with a stirrer, 200 mL of a buffer solution consisting of sodium carbonate and sodium bicarbonate was added. The mixture was placed in an ice bath, and tert-butyl dicarbonate was added dropwise using a dropping funnel. The reaction mixture was stirred in a water bath at 30°C for 22 hours. Unreacted tert-butyl dicarbonate was removed by extraction with diethyl ether (100 mL × 2). The resulting aqueous phase was adjusted to pH 2-3 with 3 mol/L hydrochloric acid solution, then extracted with ethyl acetate (100 mL × 4), dried over anhydrous sodium sulfate, filtered, and the solvent was removed by rotary evaporation to obtain a colorless, oily liquid 3-AMino-azepane-1-carboxylic acid tert-butyl ester. 
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| Chemical Properties | Back Directory | [Boiling point ]
296.5±33.0 °C(Predicted) | [density ]
1.020 | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
10.35±0.20(Predicted) | [Appearance]
Colorless to light yellow Liquid | [InChI]
InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-7-5-4-6-9(12)8-13/h9H,4-8,12H2,1-3H3/t9-/m1/s1 | [InChIKey]
WXWILWLHHQGUCX-SECBINFHSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCCC[C@@H](N)C1 | [CAS DataBase Reference]
1032684-85-7 |
| Hazard Information | Back Directory | [Uses]
(3R)-3-Aminoazepane-1-carboxylic Acid tert-Butyl Ester is used in the preparation of ureidothiophenes, as CHK1 kinase inhibitors for treating neoplasm. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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