| Identification | Back Directory | [Name]
N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-methylguanosine | [CAS]
103285-33-2 | [Synonyms]
N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-methylguanosine
Guanosine, 5'-?O-?[bis(4-?methoxyphenyl)?phenylmethyl]?-?3'-?O-?methyl-?N-?(2-?methyl-?1-?oxopropyl)?-(9CI) | [Molecular Formula]
C36H39N5O8 | [MDL Number]
MFCD31814031 | [MOL File]
103285-33-2.mol | [Molecular Weight]
669.724 |
| Hazard Information | Back Directory | [Uses]
N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. | [References]
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
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