| Identification | Back Directory | [Name]
NICLOFOLAN | [CAS]
10331-57-4 | [Synonyms]
ME 3625
Nicloflan
Bilevon M
Bayer-9015
NICLOFOLAN
Niclofoian
menichlopholan
3,3'-dichloro-5,5'-dinitro-o,o'-biphenol
4,4'-dichloro-6,6'-dinitro-o,o'-biphenol
5,5'-Dichloro-3,3'-dinitrobiphenyl-2,2'-diol
5,5'-dichloro-2,2'-dihydroxy-3,3'-dinitrobiphenyl
5,5\'-Dichloro-2,2\'-dihydroxy-3,3\'-dinitrobiphen
5,5'-dichloro-3,3'-dinitro(1,1'-biphenyl)-2,2'-diol
1'-biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-(
[1,1'-Biphenyl]-2,2'-diol,5,5'-dichloro-3,3'-dinitro- | [EINECS(EC#)]
233-720-0 | [Molecular Formula]
C12H6Cl2N2O6 | [MDL Number]
MFCD00867407 | [MOL File]
10331-57-4.mol | [Molecular Weight]
345.09 |
| Hazard Information | Back Directory | [Chemical Properties]
Orange-yellow crystalline powder. Melting point 178-182 ℃. Soluble in acetone, glacial acetic acid and sodium hydroxide solution, slightly soluble in water and ethanol. | [Uses]
Niclofolan can be used as deworming drug and anti-creep drug. It is used for prevention and treatment of hepatic chioniasis of cattle and sheep. | [Definition]
ChEBI: Niclofolan is a polychlorobiphenyl. | [Synthesis]
Niclofolan is obtained by nitration of 5,5 '-dichloro-2, 2' dihydroxybiphenyl. The nitration was carried out in acetic acid at a temperature not exceeding 20℃. Then activated carbon was added for reflux decolorization for 1h. The filter was pumped with a nitrate filter rod. The filtrate was cooled below 15℃ and crystallized. Dinitrochlorophenol was obtained by filtration, washing with acetic acid and drying. The yield is 60%. | [in vivo]
Niclofolan (2 mg/kg, intramuscular injection) is effective against fasciola hepatica infected sheep[2].
Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects against P.iloktsuenesis infected rats[4].
| Animal Model: | fasciola hepatica infected sheep[2] | | Dosage: | 2 mg/kg | | Administration: | Intramuscular injection | | Result: | Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection. |
| Animal Model: | Rats infected with P.iloktsuenesis[4] | | Dosage: | 1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times. | | Administration: | Oral gavage | | Result: | Reduced the worms in rats. |
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| Safety Data | Back Directory | [Toxicity]
bird - wild,LD50,oral,13mg/kg (13mg/kg),Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. |
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