| Identification | Back Directory | [Name]
DEVAZEPIDE | [CAS]
103420-77-5 | [Synonyms]
MK-329
L-364718
DEVAZEPIDE
EVAZEPIDE, PANOS
(3S)-1-Methyl-3-[(1H-indol-2-yl)carbonylamino]-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
(S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide
N-[(3S)-2,3-DIHYDRO-1-METHYL-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-1H-INDOLE-2-CARBOXAMIDE
1H-Indole-2-carboxamide, N-[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]- | [Molecular Formula]
C25H20N4O2 | [MDL Number]
MFCD00864500 | [MOL File]
103420-77-5.mol | [Molecular Weight]
408.45 |
| Chemical Properties | Back Directory | [Boiling point ]
758.6±60.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >5mg/mL | [form ]
powder | [pka]
13.25±0.40(Predicted) | [color ]
white to off-white | [InChI]
1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1 | [InChIKey]
NFHRQQKPEBFUJK-HSZRJFAPSA-N | [SMILES]
CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c4ccccc4)c5ccccc15 |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
28 | [Safety Statements ]
28-36/37-45 | [RIDADR ]
UN 2811 6.1 / PGI | [WGK Germany ]
3 | [RTECS ]
NL5994460 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 1 Oral |
| Hazard Information | Back Directory | [Uses]
Antagonist (cholecystokinin). | [Definition]
ChEBI: An indolecarboxamide obtained by formal condensation of the carboxy group of indole-2-carboxylic acid with the exocyclic amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one. A cholecystokinin antagonist used f
r treatment of gastrointestinal disorders. | [General Description]
Devazepide is derived from asperlicin by chemical modification and has the benzodiazepine backbone. | [Biochem/physiol Actions]
Devazepide is a CCK1 (CCK-A) receptor antagonist and a CCK8 antagonist. | [storage]
Store at +4°C |
|
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