| Identification | Back Directory | [Name]
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride | [CAS]
1035373-85-3 | [Synonyms]
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine HCl
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride
2-(2-((6-Chlorohexyl)oxy)ethoxy)ethan-1-amine hydrochloride
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylammonium hydrochloride | [Molecular Formula]
C10H23Cl2NO2 | [MOL File]
1035373-85-3.mol | [Molecular Weight]
260.2 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, sealed storage, away from moisture | [form ]
Solid | [color ]
White to yellow | [InChI]
InChI=1S/C10H22ClNO2.ClH/c11-5-3-1-2-4-7-13-9-10-14-8-6-12;/h1-10,12H2;1H | [InChIKey]
KRGPBUVQAULFOQ-UHFFFAOYSA-N | [SMILES]
C(CCCCCCl)OCCOCCN.Cl |
| Hazard Information | Back Directory | [Uses]
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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