1036915-08-8

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1036915-08-8 Structure

Identification	Back Directory
[Name] IDX-184
[CAS] 1036915-08-8
[Synonyms] IDX-184 2'-C-Methylguanosine 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate] Guanosine, 2'-C-methyl-, 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]
[Molecular Formula] C25H35N6O9PS
[MDL Number] MFCD23381633
[MOL File] 1036915-08-8.mol
[Molecular Weight] 626.62

Hazard Information	Back Directory
[Uses] IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM)[1][2].
[References] [1] Xiao-Jian Zhou , et al. Safety and Pharmacokinetics of IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor of Hepatitis C Virus, in Healthy Subjects. Antimicrob Agents Chemother. 2011 Jan;55(1):76-81. DOI:10.1128/AAC.01101-10 [2] IN VITRO ANTIVIRAL ACTIVITY AND PHARMACOLOGY OF IDX184, A NOVEL AND POTENT INHIBITOR OF HCV REPLICATION.

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