| Identification | Back Directory | [Name]
CL2-SN38 | [CAS]
1036969-20-6 | [Synonyms]
CS-2807
CL2-SN38
CL2-SN-38(DCA)
L-Lysinamide, N-[32-[4-[[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1,5-dioxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacont-1-yl]-L-phenylalanyl-N-[4-[[[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,... | [Molecular Formula]
C82H106N12O23 | [MDL Number]
MFCD32201108 | [MOL File]
1036969-20-6.mol | [Molecular Weight]
1627.81 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [solubility ]
DMSO: >1 mg/ml
Ethanol: >1 mg/ml | [form ]
Solid | [pka]
9.12±0.40(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
CL2-SN-38 is a cleavable linker-based agent-Linker conjugate, it can conjugate with the anti-Trop-2-humanized antibody hRS7. CL2-SN-38 can be used for the reasearch of cancer[1]. | [IC 50]
Camptothecins | [References]
[1] Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. DOI:10.1158/1078-0432.CCR-10-2939 |
|
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|