| Identification | Back Directory | [Name]
9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole | [CAS]
10371-86-5 | [Synonyms]
ICIG-772
NSC-69187
9-Methoxyellipticin
9-methoxyellipticine
9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole | [EINECS(EC#)]
233-812-0 | [Molecular Formula]
C18H16N2O | [MDL Number]
MFCD00049339 | [MOL File]
10371-86-5.mol | [Molecular Weight]
276.33 |
| Chemical Properties | Back Directory | [Melting point ]
286.5°C (rough estimate) | [Boiling point ]
419.24°C (rough estimate) | [density ]
1.1318 (rough estimate) | [refractive index ]
1.5700 (estimate) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
16.29±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
An Ochrosia alkaloid present in O. oppositifolia and O. sandwicensis Gray, it
occurs mainly in the bark of these species. It forms light yellow crystals and
gives an ultraviolet spectrum in EtOH with absorption maxima at 242, 275, 290
and 335 mil. It may be characterized as the hydrochloride which has m.p. 288-
290°C following a change in crystal form at 255-265°C, or as the picrate, m.p.
273-5°C. The structure has been elucidated from the mass spectrum fragmentation
pattern. | [Uses]
SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5[1]. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 72, p. 7106, 2007 DOI: 10.1021/jo070774z | [References]
Buzas, Osowiecki, Schindler., Cornpt. Rend., 247, 1390 (1958)
Goodwin, Smith, Horning.,!. Arner. Chern. Soc., 81,1903 (1959)
Mass spectrum:
Loder., Austral. J. Chern., 19, 1947 (1966)
Synthesis:
Dalton et aI., Austral. J. Chern., 20, 2715 (1967) |
|
| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|