ChemicalBook--->CAS DataBase List--->103878-84-8

103878-84-8

103878-84-8 Structure

103878-84-8 Structure
IdentificationBack Directory
[Name]

LAZABEMIDE
[CAS]

103878-84-8
[Synonyms]

LAZABEMIDE
Ro-19-6327
Ro 19-6327/000
Lazabemide hydrate
Ro 19-6327 hydrate
LAZABEMIDE HYDROCHLORIDE
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide
N-(2-aminoethyl)-5-chloropyridine-2-carboxamide
2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrate
[Molecular Formula]

C8H10ClN3O
[MDL Number]

MFCD00865419
[MOL File]

103878-84-8.mol
[Molecular Weight]

199.64
Chemical PropertiesBack Directory
[Boiling point ]

397.4±37.0 °C(Predicted)
[density ]

1.286±0.06 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMSO: ≥22mg/mL
[form ]

powder
[pka]

12.90±0.46(Predicted)
[color ]

white to tan
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-36
[Safety Statements ]

26
[WGK Germany ]

3
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Trifluoroacetic acid-->N-Boc-Ethylenediamine-->5-Chloropyridine-2-carboxylic acid
Hazard InformationBack Directory
[Uses]

Treatment of Alzheimer’s disease.
[Brand name]

Tempium (Hoffmann-LaRoche).
[Biochem/physiol Actions]

Lazabemide is effective in treatment of Alzheimer′s disease and in combination with nicotine replacement therapy aids in smoking cessation.
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