| Identification | Back Directory | [Name]
MK-4827 (R-enantioMer) | [CAS]
1038915-58-0 | [Synonyms]
ent-Niraparib
Niraparib Impurity
Niraparib R-enantiomer
MK-4827 (R-enantioMer)
R isomer of MK-4827, Niraparib
(R)-2-(4-(PIPERIDIN-3-YL)PHENYL)-2H-INDAZOLE-7-CARBOXAMIDE
2H-Indazole-7-carboxamide, 2-[4-(3R)-3-piperidinylphenyl]-
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide | [Molecular Formula]
C19H20N4O | [MOL File]
1038915-58-0.mol | [Molecular Weight]
320.39 |
| Chemical Properties | Back Directory | [Boiling point ]
463.6±45.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 32 mg/mL (99.88 mM) | [form ]
Solid | [pka]
15.36±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ent-Niraparib is an isomer of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | [Definition]
ChEBI: 2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has R-configuration. It is a potent PARP1 inhibitor with IC50 of 2.4 nM. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an antineoplastic agent. | [IC 50]
PARP-1: 2.4 nM (IC50) |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
TaiChem Taizhou Limited
|
| Tel: |
052386810091 |
| Website: |
https://www.chemicalbook.com/supplier/11410902/1.htm |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|