| Identification | Back Directory | [Name]
N,Nbis-Cbz--Alethine | [CAS]
104071-84-3 | [Synonyms]
-bis-Cbz-β-Alethine
N,Nbis-Cbz--Alethine
N,N’-bis-Cbz-β-Alethine
N,N’-bis-Cbz-β-Alethine
9,10-Dithia-2,6,13,17-tetraazaoctadecanedioic acid, 5,14-dioxo-, 1,18-bis(phenylmethyl) ester
5,?14-Dioxo-?9,?10-?dithia-?2,?6,?13,?17-?tetraazaoctadecanedi?oic Acid 1,?18-Bis(phenylmethyl) Ester | [Molecular Formula]
C26H34N4O6S2 | [MOL File]
104071-84-3.mol | [Molecular Weight]
562.7 |
| Chemical Properties | Back Directory | [Melting point ]
179-180 °C | [Boiling point ]
863.7±65.0 °C(Predicted) | [density ]
1.263±0.06 g/cm3(Predicted) | [solubility ]
DMF: 1 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
11.79±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
N,N''-bis-Cbz-β-Alethine is an active ester used in the synthesis of β-alethine, which induces cell differentiation and has potential anti-tumor applications. β-Alethine is synthesized by removing the carbobenzoxy (CBZ) groups with hydrogen bromide in glacial acetic acid. | [Uses]
5,?14-Dioxo-?9,?10-?dithia-?2,?6,?13,?17-?tetraazaoctadecanedi?oic Acid 1,?18-Bis(phenylmethyl) Ester is a used to synthesize β-alethine, a potential anti-cancer agent that induces cell differentiation. | [References]
[1] HERMAN D. SUIT MD Michael S. Hyperthermia: Potential as an anti-tumor agent[J]. Cancer, 1974, 34 1: 122-129. DOI: 10.1002/1097-0142(197407)34:1<122::aid-cncr2820340118>3.0.co;2-r
[2] Dodecahedral adenoviral complex containing penton bases and optionally fibers; adenovirus vector construction using a baculo virus in Trichoplusia ni or Spodoptera frugiperda insect cell culture, for use as a recombinant vaccine or in gene therapy[J]. Vaccine, 1997, 15 12: Page 1487. DOI: 10.1016/s0264-410x(97)84249-1
[3] G D KNIGHT. Seemingly diverse activities of beta-alethine.[J]. Cancer research, 1994, 54 21: 5636-5642.
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