| Identification | Back Directory | [Name]
YM 16638 | [CAS]
104073-72-5 | [Synonyms]
YM-638
YM 16638
YM 638|||YM-16638|||YM16638
[[5-[[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl]thio]-1,3,4-thiadiazol-2-yl]thio]acetic acid
Acetic acid, 2-[[5-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl]thio]-1,3,4-thiadiazol-2-yl]thio]-
2-[[5-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetic acid | [Molecular Formula]
C18H22N2O5S3 | [MDL Number]
MFCD01751276 | [MOL File]
104073-72-5.mol | [Molecular Weight]
442.57 |
| Hazard Information | Back Directory | [Uses]
YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC4, LTD4, and LTE4 in guinea pig trachea, with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep[1]. | [References]
[1] Tomioka K, et al. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):43-7. DOI:10.1016/0952-3278(89)90161-0 |
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