| Identification | Back Directory | [Name]
Kuguaglycoside C | [CAS]
1041631-93-9 | [Synonyms]
Momordicoside C
Kuguaglycoside C
7beta-(beta-glucopyranosyloxy)-3beta-hydroxycucurbita-5,23,25-trien-19-al
19-Norlanosta-5,23,25-triene-9-carboxaldehyde, 7-(β-D-glucopyranosyloxy)-3-hydroxy-, (3β,7β,9β,10α,23E)-
(3beta,7beta,9beta,10alpha,23E)-7-(beta-D-Glucopyranosyloxy)-3-hydroxy-19-norlanosta-5,23,25-triene-9-carboxaldehyde | [Molecular Formula]
C36H56O8 | [MDL Number]
MFCD21364048 | [MOL File]
1041631-93-9.mol | [Molecular Weight]
616.83 |
| Hazard Information | Back Directory | [Description]
Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis. | [Uses]
Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF)[1]. | [target]
PARP | Caspase | [References]
[1] Tabata K, et al. Kuguaglycoside C, a constituent of Momordica charantia, induces caspase-independent cell death of neuroblastoma cells. Cancer Sci. 2012 Dec;103(12):2153-8. DOI:10.1111/cas.12021 |
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