| Identification | Back Directory | [Name]
MANZAMINE A | [CAS]
104196-68-1 | [Synonyms]
MANZAMINE A
1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)- | [Molecular Formula]
C36H44N4O | [MDL Number]
MFCD00883806 | [MOL File]
104196-68-1.mol | [Molecular Weight]
548.76 |
| Chemical Properties | Back Directory | [Boiling point ]
756.6±60.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (up to 25 mg/ml). | [form ]
Off white to yellow solid. | [pka]
13.58±0.40(Predicted) | [color ]
Off-White to Pale Yellow | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis?in vivo2. Manzamine A displays neuritogenic activity3?and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4. | [Uses]
Manzamine A is a β-Carboline alkaloid with anti-inflammatory. | [Definition]
ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26). | [storage]
+4°C | [References]
1) Kallifatidis?et al. (2013),?The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells; Mar. Drugs,?11?3500
2) Eguchi?et al. (2013),?Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo; Bioorg. Med. Chem.,?21?3831
3) Zhang?et al. (2008),?Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. Igens (Thiele, 1899); Chem. Pharm. Bull.,?56?866
4) Hamann?et al. (2007),?Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease; J. Nat. Prod.,?70 139 |
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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