ChemicalBook--->CAS DataBase List--->104391-26-6

104391-26-6

104391-26-6 Structure

104391-26-6 Structure
IdentificationBack Directory
[Name]

CGP 25454A
[CAS]

104391-26-6
[Synonyms]

CGP 25454A
CGP25454A;CGP 25454A
[Molecular Formula]

C15H21Cl2N3O2
[MOL File]

104391-26-6.mol
[Molecular Weight]

346.25
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 3.5 mg/mL (10.11 mM)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research[1].
[Biological Activity]

CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist.
[in vitro]

CGP 25454A increase the field-stimulated [3H]- and [14C]-overflow from rat striatal slices preloaded with [3H]dopamine and [14C]choline, indicating that CGP 25454A is able to enhance the release of both dopamine (DA) and acetylcholine (ACh). However, CGP 25454A is 12.9 times more potent in increasing, by 1/6 of the apparent maximal increase, the release of [3H]DA than that of [14C]ACh.
[in vivo]

CGP 25454A increase [3H]spiperone binding to receptors of the D2 family in rat striatum by 90-110% (ED50: 13 mg/kg i.p.). As a similar increase in [3H]spiperone binding is found with a variety of agents which increase the synaptic concentration of endogenous DA, the effect of CGP 25454A most probably reflects an enhanced release of DA under in vivo conditions. At 30-100 mg/kg, CGP 25454A inhibit [3H]spiperone binding in the pituitary of the same animals as a result of a blockade of postsynaptic DA receptors.
[storage]

Store at -20°C
[References]

[1] Bischoff S et al. CGP 25454A, a novel and selective presynaptic dopamine autoreceptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep;350(3):230-8. DOI:10.1007/BF00175027
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