| Identification | Back Directory | [Name]
L-Phenylalanine, N''-[(phenylmethoxy)carbonyl]-, 2-cyano-1,2-dimethylhydrazide | [CAS]
1043922-53-7 | [Synonyms]
Gü1303
L-Phenylalanine, N''-[(phenylmethoxy)carbonyl]-, 2-cyano-1,2-dimethylhydrazide | [Molecular Formula]
C20H22N4O3 | [MOL File]
1043922-53-7.mol | [Molecular Weight]
366.42 |
| Hazard Information | Back Directory | [Uses]
Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1]. | [References]
[1] Beny?ek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526. DOI:10.1080/14756366.2021.2024527 |
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