1044904-10-0

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1044904-10-0 Structure

Identification	Back Directory
[Name] TOPOTECAN-D6
[CAS] 1044904-10-0
[Synonyms] Hycamtin-d6 TOPOTECAN-D6 NSC-609669-d6 SKF-104864A-d6 (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (4S)-10-[[Di(methyl-d₃)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
[Molecular Formula] C23H23N3O5
[MOL File] 1044904-10-0.mol
[Molecular Weight] 421.446

Chemical Properties	Back Directory
[Appearance] Light Yellow to Greenish Powder
[Melting point ] 213-218°C (dec)
[storage temp. ] -20°C Freezer
[solubility ] aqueous acid: soluble; DMSO: slightly; Methanol: soluble
[form ] A solid
[color ] Light yellow to yellow
[Stability:] Hygroscopic
[CAS DataBase Reference] 1044904-10-0

Hazard Information	Back Directory
[Chemical Properties] Light Yellow to Greenish Powder
[Uses] Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.
[Uses] Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic
[Description] Topotecan-d₆ is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC₅₀ values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC₅₀s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.
[storage] Store at -20°C

Safety Data	Back Directory
[Symbol(GHS) ] GHS08
[Signal word ] Warning
[Hazard statements ] H341
[Precautionary statements ] P201-P202-P280-P308+P313-P405-P501

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