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1046859-34-0

1046859-34-0 Structure

1046859-34-0 Structure
IdentificationBack Directory
[Name]

PF-4942847
[CAS]

1046859-34-0
[Synonyms]

PF-4942847
PF-04942487
2-Amino-4-[2,4-dichloro-6-[2-(1H-pyrazol-1-yl)ethoxy]phenyl]-5,7-dihydro-N-(2,2,2-trifluoroethyl)-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
6H-Pyrrolo[3,4-d]pyrimidine-6-carboxamide, 2-amino-4-[2,4-dichloro-6-[2-(1H-pyrazol-1-yl)ethoxy]phenyl]-5,7-dihydro-N-(2,2,2-trifluoroethyl)-
2-aMino-4-(2,4-dichloro-6-(2-(4-fluoro-4,5-dihydropyrazol-1-yl)ethoxy)phenyl)-N-(2,2,2-trifluoroethyl)-5H-pyrrolo[3,4-d]pyriMidine-6(7H)-carboxaMide
[Molecular Formula]

C20H18Cl2F3N7O2
[MOL File]

1046859-34-0.mol
[Molecular Weight]

516.3
Chemical PropertiesBack Directory
[density ]

1.64
Hazard InformationBack Directory
[Uses]

A novel potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitor of heat shock protein 90 (Hsp90). It has been shown to induce degradation of multiple client proteins, cell-cycle block, apoptosis, and inhibits cell proliferation in triple-negative breast cancer (TNBC) lines, subsequently leading to tumor growth inhibition in mouse xenograft models.
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