| Identification | Back Directory | [Name]
8-PRENYLGENISTEIN | [CAS]
104691-86-3 | [Synonyms]
Lupiwighteone
8-PRENYLGENISTEIN
8-Isopentenylgenistein
4',5,7-Trihydroxy-8-prenylisoflavone
4',5,7-Trihydroxy-8-isopentenylisoflavone
5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
3-(4-Hydroxyphenyl)-5,7-dihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)- | [Molecular Formula]
C20H18O5 | [MDL Number]
MFCD06796683 | [MOL File]
104691-86-3.mol | [Molecular Weight]
338.35 |
| Chemical Properties | Back Directory | [Melting point ]
133-135℃ | [Boiling point ]
583.5±50.0 °C(Predicted) | [density ]
1.351±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (295.55 mM; Need ultrasonic) | [form ]
Powder | [pka]
6.62±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Lupiwighteone is a natural product derivative of Genistein (G350000). Genistein exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol. | [Definition]
ChEBI: Lupiwighteone is a member of isoflavones. | [target]
PARP | Bcl-2/Bax | Caspase | Akt | CDK | ROS | P450 (e.g. CYP17) |
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| Company Name: |
Henan Alfachem Co.,Ltd.
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Wuhan Topule
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+86-02787215551 19945035818 |
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http://www.topule.com/ |
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