| Identification | Back Directory | [Name]
1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-(2-chloroacetyl)-4-(2-furanylmethyl)- | [CAS]
1047464-92-5 | [Synonyms]
ZL-Pin01
1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-(2-chloroacetyl)-4-(2-furanylmethyl)- | [Molecular Formula]
C14H17ClN2O3S | [MOL File]
1047464-92-5.mol | [Molecular Weight]
328.81 |
| Hazard Information | Back Directory | [Uses]
ZL-Pin01 is a high potent covalent Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC50 of 1.33 μM[1]. | [References]
[1] Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J Med Chem. 2022;65(3):2174-2190. DOI:10.1021/acs.jmedchem.1c01686 |
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