| Identification | Back Directory | [Name]
TA 7552 | [CAS]
104756-72-1 | [Synonyms]
TA 7552
4-(3,4-DIMETHOXY-PHENYL)-1-HYDROXY-5,6,7-TRIMETHOXY-NAPHTHALENE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER
2,3-Naphthalenedicarboxylic acid, 4-(3,4-dimethoxyphenyl)-1-hydroxy-5,6,7-trimethoxy-, 2,3-dimethyl ester | [Molecular Formula]
C25H26O10 | [MDL Number]
MFCD00932291 | [MOL File]
104756-72-1.mol | [Molecular Weight]
486.47 |
| Hazard Information | Back Directory | [Uses]
TA 7552, is a potent cholesterol-lowering agent. | [in vivo]
TA-7552 is a potent cholesterol-lowering agent. When TA-7552 is mixed with unsupplemented CLEA CE-2 powder in a concentration of 0.05% and administered to rats for 7 days, TA-7552 does not reduce the normal level of serum cholesterol. The hypocholesterolemic effect of TA-7552 is apparent at the lowest concentration (0.01%) of the drug in the diet, corresponding to a daily dose of ~10 mg/kg body weight, and maximal at the highest concentration of 0.2% TA-7552, lowering serum total cholesterol by 72% while elevating serum HDL cholesterol by 88%. TA-7552 also dose dependently suppresses this rise of hepatic cholesterol, and its lowering rate at the maximal dose is 90%[1]. |
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