| Identification | Back Directory | [Name]
API-1252 tosylate | [CAS]
1047981-31-6 | [Synonyms]
AFN-1252 tosylate
API-1252 tosylate
AFN 1252 tosylate,AFN1252 tosylate | [Molecular Formula]
C29H29N3O6S | [MOL File]
1047981-31-6.mol | [Molecular Weight]
547.63 |
| Hazard Information | Back Directory | [Uses]
AFN-1252 (API-1252) tosylate is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 tosylate exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 tosylate exhibits typical MIC90 values of 0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 tosylate is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith[1][2]. | [References]
[1] Nachum Kaplan, et al. In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics. J Chemother. 2013 Feb;25(1):18-25. DOI:10.1179/1973947812Y.0000000063
[2] Nachum Kaplan,et al. Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitor. Antimicrob Agents Chemother. 2012 Nov;56(11):5865-74. DOI:10.1128/AAC.01411-12 |
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