| Identification | Back Directory | [Name]
AB 1010 Mesylate | [CAS]
1048007-93-7 | [Synonyms]
AB1010 Mesylate
AB-1010 Mesylate
Masivet Mesylate
AB 1010 Mesylate
Masitinib (Mesylate)
Masitinib mesylate
(AB1010 mesylate
AB1010 MESYLATE;AB-1010 MESYLATE;AB 1010 MESYLATE
AB1010 MESYLATE; MASIVET MESYLATE; AB-1010 MESYLATE; AB 1010 MESYLATE
N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide methanesulfonate
Benzamide,4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-,methanesulfonate
methanesulfonicacid,4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide | [Molecular Formula]
C29H34N6O4S2 | [MOL File]
1048007-93-7.mol | [Molecular Weight]
594.748 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 30 mg/mL (50.44 mM) | [form ]
Powder | [color ]
White to yellow | [InChIKey]
TXCWBWKVIZGWEQ-UHFFFAOYSA-N | [SMILES]
CS(O)(=O)=O.C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)(=O)C1=CC=C(CN2CCN(C)CC2)C=C1 |
| Hazard Information | Back Directory | [Uses]
Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively. | [Uses]
Masitinib Mesylate can be used to treat sickle cell disease. | [Synthesis]
Synthesis of N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide and methanesulfonic acid as 4-[(4-methyl-1-piperazinyl)methyl]-N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamidic acid The general procedure for the sulfonate is as follows: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide (1.0 eq.) was dissolved in ethanol (4.5 v/v), and heated to 65-70°C to dissolve it completely. Under the condition of maintaining the same temperature, methanesulfonic acid (1.0 eq.) was slowly added. Upon completion of the reaction, the mixture was cooled to 25-30 °C and kept at this temperature for 6 hours to promote crystallization. The product was collected by filtration and dried in a vacuum disk dryer at 55-60°C. The yield of this step was 85-90% and the starting melting point of the product was 236°C. | [in vivo]
Masitinib inhibits tumour growth and increases the median survival time in Δ27-expressing Ba/F3 tumor models at 30 mg/kg, without cardiotoxicity or genotoxicity[1].
Masitinib (12.5 mg/kg/d, p.o.) increases overall TTP (time-to-tumor progression) compared with placebo in dogs[3]. | [storage]
Store at -20°C | [References]
[1] Patent: WO2008/98949, 2008, A2. Location in patent: Page/Page column 23 |
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BOC Sciences
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16314854226 |
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www.bocsci.com |
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