| Identification | Back Directory | [Name]
DEAMIDO NAD SODIUM SALT | [CAS]
104809-30-5 | [Synonyms]
NAAD
NAAD Na
deamido nad
NAAD Na salt
NAAD Na, NaAD
NAAD SODIUM SALT
Nicotinic acid NAD
DEAMIDO NAD SODIUM SALT
NICOTINIC ACID NAD SODIUM SALT
nicotinic acid adenine dinucleotide*sodium
Deamido NAD, NAAD, Nicotinic acid NAD
NICOTINIC ACID ADENINE DINUCLEOTIDE SODIUM SALT
Nicotinic acid adenine dinucleotide sodium salt >=98%
Endogenous Metabolite,Deamido nad,NAD+,synthetase,Inhibitor,NAAD,adenylyltransferases,inhibit,mononucleotide,nicotinate
5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl][5-(3-carboxypyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methylphosphate,sodium | [Molecular Formula]
C21H25N6NaO15P2 | [MDL Number]
MFCD00082430 | [MOL File]
104809-30-5.mol | [Molecular Weight]
686.39 |
| Hazard Information | Back Directory | [Uses]
Nicotinic acid adenine dinucleotide sodium salt has been used as an internal standard during high performance liquid chromatography (HPLC) metabolite measurement. It has also been used as a substrate in nicotinamide adenine dinucleotide (NAD) biosynthesis. | [General Description]
Nicotinic acid adenine dinucleotide (deamido-NAD, NAAD) is a closely related analog of NAD+. It is used to study the structure of nicotinate mononucleotide adenylyltransferase(s) (NMN/NaMN). NAAD is used as a substrate to study the specificity and kinetics of nicotinamide adenine dinucleotide synthetase(s) (NADS). In addition, it is also used as a co-substrate to study mechanisms of members of the Sir2 class of NAD+-dependent deacetylase. | [in vivo]
In mice, when nicotinic acid (NA) is provided by oral gavage, liver NA peaked (340 pmol/mg) in 15 min. Hepatic NA appearance is followed by an expected peak of 220 NAAD sodium at 1 h post gavage and a rise in hepatic NAD+ from 990 baseline to 2200 at 2 h[1].
NAAD sodium is reported in mouse liver when 500 mg/kg of radioactive nicotinamide (Nam) is injected intraperitoneally (IP) into the body cavity of mice. However, NAAD sodium is observed in kidneys, ovaries, lung, heart and brain in addition to liver in mice IP-injected with 500 mg/kg of NA but not Nam[1]. |
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