| Identification | Back Directory | [Name]
H-TYR-TYR-OH | [CAS]
1050-28-8 | [Synonyms]
TYR-TYR
H-TYR-TYR-OH
tyrosyltyrosine
TYR-TYR CRYSTALLINE
L-TYROSYL-L-TYROSINE
L-Tyrosine, L-tyrosyl-
Peptide tyrosine-tyrosine
(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propionic acid
(2S)-2-[[(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid | [Molecular Formula]
C18H20N2O5 | [MDL Number]
MFCD00063044 | [MOL File]
1050-28-8.mol | [Molecular Weight]
344.36 |
| Chemical Properties | Back Directory | [Melting point ]
300 °C (decomp) | [Boiling point ]
703.1±60.0 °C(Predicted) | [density ]
1.372±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [form ]
Solid | [pka]
pK1:3.52(+1);pK2:7.68(0);pK3:9.80(+1);pK4:10.26(+2) (25°C) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
H-TYR-TYR-OH (cas# 1050-28-8) is an antihypertensive peptide with angiotensin I-converting enzyme (ACE) inhibitory activity prepared from the powder of the jellyfish. | [Definition]
ChEBI: Tyrosyltyrosine in which each tyrosine residue has L-configuration. | [in vivo]
H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo[1].
H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats[1]. | Animal Model: | Anesthetized male SpragueDawley rats[1] | | Dosage: | 12.5 mg/kg | | Administration: | Intraarterial injection; 12.5 mg/kg once | | Result: | Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.
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| Animal Model: | Spontaneously hypertensive rats[1] | | Dosage: | 0, 50 and 100 mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Nextpeptide Inc
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| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
| Company Name: |
Binhai gill polypeptide co. LTD
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| Telephone: |
021-61263389 13524856427 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList326362/0_EN.htm |
| Company Name: |
Ontores Biotech
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| Telephone: |
0571-88760729 18072970094 |
| Website: |
www.ontoresinc.cn |
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