1050480-30-2

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1050480-30-2 Structure

Identification	Back Directory
[Name] PhiKan 083 hydrochloride
[CAS] 1050480-30-2
[Synonyms] PhiKan083 hydrochloride >=98% (HPLC)
[Molecular Formula] C16H19ClN2
[MOL File] 1050480-30-2.mol
[Molecular Weight] 274.79

Chemical Properties	Back Directory
[storage temp. ] Store at -20°C
[solubility ] Soluble to 50 mM in water and to 100 mM in DMSO
[form ] Solid
[color ] White to off-white
[Water Solubility ] Water: 2 mg/mL (7.28 mM and warming)

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H315-H319
[Precautionary statements ] P305+P351+P338

Hazard Information	Back Directory
[Uses] PhiKan-083 is a p53 stabilizing agent. PhiKan-083 preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. PhiKan-083 slows rate of thermal denaturation of p53-Y220C.
[Biological Activity] PhiKan083 is a small molecule th at binds within a cavity on the surface of Y220C-mutated p53. This mutationwhich is not involved in DNA interactioncauses a destabilization of the protein. PhiKan083 binding acts to stabilize the mutant p53 and slow the rate of denaturation.
[storage] Store at +4°C

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