| Identification | Back Directory | [Name]
Torbafylline | [CAS]
105102-21-4 | [Synonyms]
HWA-448
Torbafylline
7-(Ethoxymethyl)-1-(5-hydroxy-5-methylhexyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
1H-Purine-2,6-dione, 7-(ethoxymethyl)-3,7-dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl- | [Molecular Formula]
C16H26N4O4 | [MDL Number]
MFCD00867585 | [MOL File]
105102-21-4.mol | [Molecular Weight]
338.4 |
| Hazard Information | Back Directory | [Uses]
Torbafylline is a PDE inhibitor. Torbafylline mitigates protein breakdown in rat skeletal muscle following burns by activating the PDE4/cAMP/EPAC/PI3K/Akt signaling pathway. Torbafylline suppresses the increased ubiquitin-proteasome-dependent protein degradation observed in the skeletal muscles of rats susceptible to cancer and sepsis[1]. | [References]
[1] Okyayuz-Baklouti I. The effects of torbafylline on blood flow, pO2 and function of rat ischaemic skeletal muscle. Eur J Pharmacol. 1989 Jul 4;166(1):75-86. DOI:10.1016/0014-2999(89)90685-7 |
|
|