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105102-21-4

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105102-21-4 Structure

105102-21-4 Structure
IdentificationBack Directory
[Name]

Torbafylline
[CAS]

105102-21-4
[Synonyms]

HWA-448
Torbafylline
7-(Ethoxymethyl)-1-(5-hydroxy-5-methylhexyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
1H-Purine-2,6-dione, 7-(ethoxymethyl)-3,7-dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl-
[Molecular Formula]

C16H26N4O4
[MDL Number]

MFCD00867585
[MOL File]

105102-21-4.mol
[Molecular Weight]

338.4
Chemical PropertiesBack Directory
[Boiling point ]

534.7±60.0 °C(Predicted)
[density ]

1.25±0.1 g/cm3(Predicted)
[pka]

15.28±0.29(Predicted)
Hazard InformationBack Directory
[Uses]

Torbafylline is a PDE inhibitor. Torbafylline mitigates protein breakdown in rat skeletal muscle following burns by activating the PDE4/cAMP/EPAC/PI3K/Akt signaling pathway. Torbafylline suppresses the increased ubiquitin-proteasome-dependent protein degradation observed in the skeletal muscles of rats susceptible to cancer and sepsis[1].
[References]

[1] Okyayuz-Baklouti I. The effects of torbafylline on blood flow, pO2 and function of rat ischaemic skeletal muscle. Eur J Pharmacol. 1989 Jul 4;166(1):75-86. DOI:10.1016/0014-2999(89)90685-7
Spectrum DetailBack Directory
[Spectrum Detail]

Torbafylline(105102-21-4)1HNMR
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