| Identification | Back Directory | [Name]
6,7-Di-O-acetylsinococuline | [CAS]
1054312-81-0 | [Synonyms]
FK-3000
6,7-Di-O-acetylsinococuline
Morphinan-4,6,7-triol, 8,14-didehydro-3,8-dimethoxy-, 6,7-diacetate, (6β,7β,9α,13α)- | [Molecular Formula]
C22 H27 N O7 | [MOL File]
1054312-81-0.mol | [Molecular Weight]
417.45 |
| Hazard Information | Back Directory | [Uses]
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and HIV-1[1][2][3][4]. | [in vivo]
FK-3000 (1 mg/kg/day; i.p. daily for 24 d) inhibits tumor growth and shows no signs of toxicity in an MDA-MB-231 xenografted mouse model[1].
FK-3000 (10-25 mg/kg; p.o. for 10 d) significantly delays skin lesion, limits the development of further lesions and prolongs the mean survival time of HSV-1 infected mice[3]. | [References]
[1] Xu HD, et, al. FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. Int J Oncol. 2015;46(6):2309-16. DOI:10.3892/ijo.2015.2940
[2] Li YC, et, al. 6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation. Int J Oncol. 2015 Feb;46(2):578-86. DOI:10.3892/ijo.2014.2739
[3] Nawawi A, et, al. In vivo antiviral activity of Stephania cepharantha against herpes simplex virus type-1. Phytother Res. 2001 Sep;15(6):497-500. DOI:10.1002/ptr.881
[4] Lee JH, et, al. Development of a LC-MS method for quantification of FK-3000 and its application to in vivo pharmacokinetic study in drug development. J Pharm Biomed Anal. 2012 Nov;70:587-91. DOI:10.1016/j.jpba.2012.05.030 |
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