| Identification | Back Directory | [Name]
Dopamine D2 receptor antagonist-1 | [CAS]
1055411-77-2 | [Synonyms]
Dopamine D2 receptor antagonist-1
[1]Benzothieno[2,3-d]pyrimidin-4-amine, N-cyclobutyl-5,6,7,8-tetrahydro-
Dopamine D-2 receptor antagonist-1,Dopamine D2 receptor antagonist 1,Dopamine D2 receptor antagonist1 | [Molecular Formula]
C14H17N3S | [MDL Number]
MFCD32671363 | [MOL File]
1055411-77-2.mol | [Molecular Weight]
259.37 |
| Chemical Properties | Back Directory | [Boiling point ]
465.5±40.0 °C(Predicted) | [density ]
1.345±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.66±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity[1]. | [References]
[1] Fyfe TJ, et al. Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D2 receptor. Eur J Med Chem. 2019 Apr 15;168:474-490. DOI:10.1016/j.ejmech.2019.01.061 |
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