| Hazard Information | Back Directory | [Description]
L-threo Lysosphingomyelin is an endogenous bioactive sphingolipid and isomer of lysosphingomyelin .1 It is an agonist of sphingosine-1-phosphate (S1P) receptors 1-3 (EC50s = 19.3, 313.3, and 131.8 nM for human S1P1-3, respectively). As this product is derived from a natural source, there may be variations in the sphingoid backbone. | [Uses]
L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent S1P receptor agonist with EC50s of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively[1]. | [IC 50]
S1PR1: 19.3 nM (EC50, human); S1PR3: 131.8 nM (EC50, human); S1PR2: 313.3 nM (EC50, human) | [References]
1. Im, D.-S., Clemens, J., Macdonald, T.L., et al. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): Structure-activity relationship of sphingosine1-phosphate receptors Biochemistry 40(46),14053-14060(2001). |
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Alfa Chemistry
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1-516-6625404 |
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https://www.alfa-chemistry.com |
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Enzo Biochem Inc
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Enzo Biochem Inc. 13797054060 |
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www.enzo.com |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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www.biorbyt.com |
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