| Identification | Back Directory | [Name]
AT-13148 | [CAS]
1056901-62-2 | [Synonyms]
CS-1252
AT-13148
AT13148 HCl
AT13148, >=98%
AT-13148;AT 13148
AT-13148 USP/EP/BP
AT13148 hydrochloride
AT 13148 dihydrochloride
AT-13148; AT 13148; AT13148; AT13148 HYDROCHLORIDE; AT13148 HCL
(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
(1S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol
(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol
Benzenemethanol, α-(aminomethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-, (αS)-
(alphaS)-alpha-(Aminomethyl)-alpha-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)benzenemethanol
(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol AT13148 | [Molecular Formula]
C17H16ClN3O | [MDL Number]
MFCD25976789 | [MOL File]
1056901-62-2.mol | [Molecular Weight]
313.781 |
| Chemical Properties | Back Directory | [Boiling point ]
595.9±50.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
10.92±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor. | [Biological Activity]
at13148 is a novel, oral and atp-competitive inhibitor of multi-agc kinase with ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm for akt, p70s6 kinase, pka, sgk and rho kinase, respectively [1]. | [in vitro]
studies, at13148 has been reported to inhibit activity of agc kinases which including akt, p70s6 kinase, pka, sgk and rho kinase with the ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm, respectively. in addition, at13148 has been revealed to inhibit proliferation with gi50 values of 1.54μm, 1.59μm, 1.82μm, 2.65μm and 3.77μm in mes-sa, bt474, hct-116, a549 and sk-ov-3 cell lines, respectively. | [in vivo]
studies, at13148 has shown the antitumor activity in multiple human tumor xenograft models including pten-deficient mes-sa human uterine sarcoma, her2-positive, pik3ca-mutant bt474 human breast cancer xenografts [1]. | [IC 50]
Akt1: 38 nM (IC50); p70S6K: 8 nM (IC50); Akt3: 50 nM (IC50); Akt2: 402 nM (IC50); PKA: 3 nM (IC50); ROCKII: 4 nM (IC50); ROCKI: 6 nM (IC50); SGK3: 63 nM (IC50); RSK1: 85 nM (IC50); CHK2: 860 nM (IC50); Aurora B: 1840 nM (IC50) | [storage]
Store at -20°C | [References]
[1] yap ta1, walton mi, grimshaw km, te poele rh, eve pd, valenti mr, de haven brandon ak, martins v, zetterlund a, heaton sp, heinzmann k, jones ps, feltell re, reule m, woodhead sj, davies tg, lyons jf, raynaud fi, eccles sa, workman p, thompson nt, garrett md. at13148 is a novel, oral multi-agc kinase inhibitor with potent pharmacodynamic and antitumor activity. clin cancer res. 2012 jul 15;18(14):3912-23. |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|