| Identification | Back Directory | [Name]
15-KEDE | [CAS]
105835-44-7 | [Synonyms]
15-KEDE
15-OXOEDE
QZCMHXPXGACWLJ-QWAPPMFBSA-N
15-OXO-11Z,13E-EICOSADIENOIC ACID
(11Z,13E)-15-oxoicosa-11,13-dienoic acid
11,13-Eicosadienoic acid, 15-oxo-, (11Z,13E)- | [Molecular Formula]
C20H34O3 | [MDL Number]
MFCD00216128 | [MOL File]
105835-44-7.mol | [Molecular Weight]
322.48 |
| Chemical Properties | Back Directory | [Boiling point ]
477.8±18.0 °C(Predicted) | [density ]
0.955±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml | [pka]
4.78±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 μM, which is about 2-fold lower than 15(S)-HEDE. A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity. | [Definition]
ChEBI: 15-oxoEDE is an oxoeicosadienoic acid that consists of 11Z,13E-oxoeicosadienoic acid with the oxo substituent located at position 15. It has a role as a metabolite. It is an OxoEDE and an enone. It is functionally related to a 15-HEDE. It is a conjugate acid of a 15-oxo-EDE(1-). |
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