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1058691-77-2

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1058691-77-2 Structure

1058691-77-2 Structure
IdentificationBack Directory
[Name]

m-PEG7-aldehyde
[CAS]

1058691-77-2
[Synonyms]

MPEG7-ALD
mPEG7-CHO
mPEG7-pAld
m-PEG7-aldehyde
m-PEG9-aldehyde
MPEG7-CH2CH2CHO
m-PEG6-CH2CH2CHO
4,7,10,13,16,19,22-Heptaoxatricosanal
[Molecular Formula]

C16H32O8
[MDL Number]

MFCD28976707
[MOL File]

1058691-77-2.mol
[Molecular Weight]

352.42
Chemical PropertiesBack Directory
[solubility ]

Soluble in Water, DMSO, DCM, DMF
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

m-PEG7-aldehyde is a PEG reagent containing an aldehyde group. Aldehyde can react with hydrazide and aminooxy groups for labeling and crosslinking carbonyls.
[Biological Activity]

M-PEG7-aldehyde is a non-cleavable ADC linker for antibody drug conjugate (ADC) synthesis,it is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[target]

Non-cleavable

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PEGs

Spectrum DetailBack Directory
[Spectrum Detail]

m-PEG7-aldehyde(1058691-77-2)1HNMR
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