| Identification | Back Directory | [Name]
4-Hydroxy-TeriflunoMide | [CAS]
1058722-45-4 | [Synonyms]
4-Hydroxy-TeriflunoMide
Teriflunomide 4-Hydroxy
Teriflunomide Impurity 8
WHYQOFDUXDGMTM-KTKRTIGZSA-N
(Z)-2-cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
(2Z)-2-Cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
2-Butenamide, 2-cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)- | [Molecular Formula]
C12H9F3N2O3 | [MOL File]
1058722-45-4.mol | [Molecular Weight]
286.21 |
| Chemical Properties | Back Directory | [InChI]
InChI=1S/C12H9F3N2O3/c13-12(14,15)7-1-3-8(4-2-7)17-11(20)9(5-16)10(19)6-18/h1-4,18-19H,6H2,(H,17,20)/b10-9- | [InChIKey]
WHYQOFDUXDGMTM-KTKRTIGZSA-N | [SMILES]
C(NC1=CC=C(C(F)(F)F)C=C1)(=O)/C(/C#N)=C(\O)/CO |
| Hazard Information | Back Directory | [Uses]
4-Hydroxy-Teriflunomide is a metabolite of Leflunomide (L322750), an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index). | [Uses]
4-Hydroxy-Teriflunomide is a metabolite of Leflunomide (L322750), an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research. |
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
| Company Name: |
NE Scientific
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+1 (617) 651-6662 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19253/0_EN.htm |
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