| Identification | Back Directory | [Name]
2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE | [CAS]
10592-27-5 | [Synonyms]
7-azaindoline
2,3-Dihydro-7-azaindole
2,3-Dihydro-7-azaindole 98%
1H,2H,3H-pyrrolo[2,3-b]pyridine
2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE
2,3-Dihydropyrrolo[2,3-b]pyridine, 97+%
1H-Pyrrolo[2,3-b]pyridine, 2,3-dihydro-
1H-Pyrrolo[2,3-b]pyridine,2,3-dihydro-(6CI,8CI,9CI)
2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine 7-azaindoline | [Molecular Formula]
C7H8N2 | [MDL Number]
MFCD06659751 | [MOL File]
10592-27-5.mol | [Molecular Weight]
120.15 |
| Chemical Properties | Back Directory | [Melting point ]
78-83 °C | [Boiling point ]
114°C/10mmHg(lit.) | [density ]
1.23 | [storage temp. ]
Room temperature. | [solubility ]
soluble in Methanol | [form ]
Powder | [pka]
10.75±0.20(Predicted) | [color ]
White | [Water Solubility ]
Slightly soluble in water. | [λmax]
306nm(Cyclohexane)(lit.) | [InChI]
1S/C7H8N2/c1-2-6-3-5-9-7(6)8-4-1/h1-2,4H,3,5H2,(H,8,9) | [InChIKey]
ZFFYPGZDXUPKNK-UHFFFAOYSA-N | [SMILES]
C1Cc2cccnc2N1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-36 | [Safety Statements ]
36 | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
Beige powder | [Uses]
It can be used as pharmaceutical raw material and intermediate. | [Synthesis]
a) 7-azaindole (100 g, 0.846 mol), Ni/Al?O? catalyst (12 g, 10 wt%), and toluene (200 g) were added to the autoclave and stirred and mixed homogeneously to obtain the reaction solution A; b) the autoclave was replaced with nitrogen for 8 times, followed by hydrogen for 4 times to ensure that the reaction system was oxygen-free; c) the reaction solution A was subjected to hydrogenation reaction at a pressure of 2 MPa hydrogen and 130 °C; d) after the completion of the reaction, the hydrogenation mixture was filtered to remove the catalyst to obtain the filtrate B; e) after distillation and recovery of the organic solvent from the filtrate B, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine (94.59 g, 93.4% yield) was obtained, and the purity of the product was analyzed by gas chromatography, which was ≥98%. | [References]
[1] Patent: CN107987076, 2018, A. Location in patent: Paragraph 0043-0047; 0058-0063; 0075-0079
[2] Patent: CN106188050, 2016, A. Location in patent: Paragraph 0016
[3] Patent: US2011/144105, 2011, A1. Location in patent: Page/Page column 16
[4] Synthesis, 2005, # 15, p. 2503 - 2506
[5] Patent: WO2004/78757, 2004, A2. Location in patent: Page 32; 48-49 |
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