| Identification | Back Directory | [Name]
N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]OCTADECANAMIDE | [CAS]
105955-10-0 | [Synonyms]
STEARDA
N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]OCTADECANAMIDE
Octadecanamide, N-[2-(3,4-dihydroxyphenyl)ethyl]- | [Molecular Formula]
C26H45NO3 | [MDL Number]
MFCD08703100 | [MOL File]
105955-10-0.mol | [Molecular Weight]
419.64 |
| Hazard Information | Back Directory | [Uses]
STEARDA is a novel, endogenous capsaicin-like lipid that produces hyperalgesia. | [Definition]
ChEBI: N-stearoyl dopamine is a carboxamide. It is functionally related to a dopamine. | [Biological Activity]
Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB 1 receptors (at concentrations up to 5 μ M) and does not inhibit AMT or FAAH (IC 50 > 25 μ M). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo ; enhances effects on intracellular Ca 2+ (EC 50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC 50 = 16 nM). |
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