| Identification | Back Directory | [Name]
[1]Benzothieno[2,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-3-[(2-methoxy-1-naphthalenyl)methyl]-7-[(3-pyridinylmethyl)amino]- | [CAS]
1060430-64-9 | [Synonyms]
ICLSIRT078
ICL-SIRT078
ICL SIRT078
ICL-SIRT-078
ICL SIRT 078
[1]Benzothieno[2,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-3-[(2-methoxy-1-naphthalenyl)methyl]-7-[(3-pyridinylmethyl)amino]- | [Molecular Formula]
C28H26N4O2S | [MOL File]
1060430-64-9.mol | [Molecular Weight]
482.6 |
| Hazard Information | Back Directory | [Description]
ICL-SIRT078 is a highly selective, substrate-competitive SIRT2 inhibitor. It acts by displaying a significant neuroprotective effect in a lactacystin-induced model of Parkinsonian neuronal cell death in the N27 cell line. | [Uses]
ICL-SIRT078 is an active compound. | [References]
[1] The Discovery of a Highly Selective 5,6,7,8‐Tetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson's?…
[2] Thienopyrimidinone based sirtuin-2 (SIRT2)-selective inhibitors bind in the ligand induced selectivity pocket |
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