| Identification | Back Directory | [Name]
METHYL 4-(4-PYRIDINYL)BENZOATE | [CAS]
106047-17-0 | [Synonyms]
AKOS BAR-0605
METHYL 4-PYRIDIN-4-YL-BENZATE
Methyl 4-(pyridin-4-yl)benoate
METHYL 4-(4-PYRIDINYL)BENZOATE
METHYL 4-(PYRIDIN-4-YL)BENZOATE
Benzoic acid, 4-(4-pyridinyl)-, methyl ester | [Molecular Formula]
C13H11NO2 | [MDL Number]
MFCD04114575 | [MOL File]
106047-17-0.mol | [Molecular Weight]
213.23 |
| Chemical Properties | Back Directory | [Melting point ]
103-105℃ | [Boiling point ]
160 °C(Press: 1 Torr) | [density ]
1.147 | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
4.98±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
Step A: 4-Bromopyridine (3.0 g, 19.0 mmol), 4-methoxycarbonylphenylboronic acid (2.63 g, 14.6 mmol), Pd(PPh3)2Cl2 (0.35 g, 0.5 mmol) and sodium carbonate (6.91 g, 65.2 mmol) were dissolved in 1,2-dimethoxyethane (40 mL) under nitrogen protection. The reaction mixture was heated to 90 °C and stirred for 10 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 6:1 to 2:1) to afford methyl 4-(pyridin-4-yl)benzoate (2.7 g, yield: 86.8%) as a white solid. m/z MS (ESI): 214 [M+H]+. | [References]
[1] Patent: EP3190113, 2017, A1. Location in patent: Paragraph 0101
[2] Patent: TWI558709, 2016, B. Location in patent: Page/Page column 50; 51
[3] Patent: US2004/242572, 2004, A1. Location in patent: Page/Page column 73 |
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| Company Name: |
Aemon Chemical
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| Tel: |
0086-755-86198205 |
| Website: |
www.aemonchem.com |
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